Role of mucociliary clearance system in respiratory diseases.
10.11817/j.issn.1672-7347.2023.220372
- Author:
Di WU
1
;
Yang XIANG
2
Author Information
1. Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410013, China. Doctorwu0724@163.com.
2. Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410013, China. xiangyang@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
asthma;
chronic obstructive pulmonary disease;
cystic fibrosis;
mucociliary clearance system;
primary ciliary dysfunction
- MeSH:
Humans;
Mucociliary Clearance;
Respiratory Tract Diseases;
Pulmonary Disease, Chronic Obstructive/metabolism*;
Mucus/metabolism*;
Lung;
Respiratory System
- From:
Journal of Central South University(Medical Sciences)
2023;48(2):275-284
- CountryChina
- Language:English
-
Abstract:
Mucociliary clearance system is the primary innate defense mechanism of the lung. It plays a vital role in protecting airways from microbes and irritants infection. Mucociliary clearance system, which is mediated by the actions of airway and submucosal gland epithelial cells, plays a critical role in a multilayered defense system via secreting fluids, electrolytes, antimicrobial and anti-inflammatory proteins, and mucus onto airway surfaces. Changes in environment, drugs or diseases can lead to mucus overproduction and cilia dysfunction, which in turn decrease the rate of mucociliary clearance and enhance mucus gathering. The dysfunction of mucociliary clearance system often occurs in several respiratory diseases, such as primary ciliary dysfunction, cystic fibrosis, asthma and chronic obstructive pulmonary disease, which are characterized by goblet cell metaplasia, submucosal gland cell hypertrophy, mucus hypersecretion, cilia adhesion, lodging and loss, and airway obstruction.
