Effect of exosomes as drug carriers in chemotherapy of pancreatic cancer.
10.11817/j.issn.1672-7347.2023.220439
- Author:
Biaoming XU
1
,
2
;
Chaohui ZUO
3
,
4
Author Information
1. Hengyang Medical School, University of South China
2. Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Hunan 421001. xubiaoming@163.com.
3. Department of Gastroduodenal and Pancreatic Surgery, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University ＆ Hunan Cancer Hospital
4. Translational Medicine Research Center of Liver Cancer and Laboratory of Digestive Oncology of Hunan Cancer Hospital & Hunan Cancer Control Institute, Changsha 410013, China. zuochaohui@vip.sina.com.
- Publication Type:Journal Article
- Keywords:
chemotherapy;
drug carriers;
drug resistance;
exosomes;
pancreatic cancer
- MeSH:
Humans;
Exosomes/metabolism*;
Drug Carriers/metabolism*;
Pancreatic Neoplasms/diagnosis*;
Antineoplastic Agents/therapeutic use*
- From:
Journal of Central South University(Medical Sciences)
2023;48(2):268-274
- CountryChina
- Language:English
-
Abstract:
Pancreatic cancer (PC) is a malignant tumor of the digestive tract with poor patient prognosis. The PC incidence is still increasing with a 5-year survival rate of only 10%. At present, surgical resection is the most effective method to treat PC, however, 80% of the patients missed the best time for surgery after they have been diagnosed as PC. Chemotherapy is one of the main treating methods but PC is insensitive to chemotherapy, prone to drug resistance, and is accompanied by many side effects which are related to a lack of specific target. Exosomes are nanoscale vesicles secreted by almost all cell types and can carry various bioactive substances which mediate cell communication and material transport. They are characterized by a low immunogenicity, low cytotoxicity, high penetration potential and homing capacity, and possess the potential of being used as advanced drug carriers. Therefore, it is a hot research topic to use drug-loaded exosomes for tumor therapy. They may alleviate chemotherapy resistance, reduce side effects, and enhance the curative effect. In recent years, exosome drug carriers have achieved considerable results in PC chemotherapy studies.
