Research progress in effects of pyroptosis on intestinal inflammatory injury.
10.11817/j.issn.1672-7347.2023.220337
- Author:
Dandan LIU
1
;
Xiaolin ZHONG
2
;
Wenyu CAO
3
;
Ling CHEN
4
Author Information
1. Department of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001. 714036750@qq.com.
2. Department of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001.
3. Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China.
4. Department of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001. lingchen-cl@outlook.com.
- Publication Type:Journal Article
- Keywords:
infectious enteritis;
inflammation;
inflammatory bowel diseases;
intestinal inflammatory injury;
intestinal tumor;
pyroptosis;
sepsis
- MeSH:
Humans;
Pyroptosis;
Inflammasomes/metabolism*;
Apoptosis;
Caspase 1;
Inflammation
- From:
Journal of Central South University(Medical Sciences)
2023;48(2):252-259
- CountryChina
- Language:English
-
Abstract:
Inflammatory injury of the intestine is often accompanied by symptoms such as damage to intestinal mucosa, increased intestinal permeability, and intestinal motility dysfunction. Inflammatory factors spread throughout the body via blood circulation, and can cause multi-organ failure. Pyroptosis is a newly discovered way of programmed cell death, which is mainly characterized by the formation of plasma membrane vesicles, cell swelling until the rupture of the cell membrane, and the release of cell contents, thereby activating a drastic inflammatory response and expanding the inflammatory response cascade. Pyroptosis is widely involved in the occurrence of diseases, and the underlying mechanisms for inflammation are still a hot spot of current research. The caspase-1 mediated canonical inflammasome pathway of pyroptosis and caspase-4/5/8/11-mediated non-canonical inflammasome pathway are closely related to the occurrence and development of intestinal inflammation. Therefore, investigation of the signaling pathways and molecular mechanisms of pyroptosis in intestinal injury in sepsis, inflammatory bowel diseases, infectious enteristic, and intestinal tumor is of great significance for the prevention and treatment of intestinal inflammatory injury.
