Correlation between urine vitamin D -binding protein and early -stage renal damage in Type 2 diabetes.
10.11817/j.issn.1672-7347.2023.210701
- Author:
Yuxi HUANG
1
;
Sijie CHEN
2
;
Qing DAI
2
;
Hao ZHANG
2
;
Yan LIU
3
Author Information
1. Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013. 309536324@qq.com.
2. Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013.
3. Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013. 42730339@qq.com.
- Publication Type:Journal Article
- Keywords:
diabetic mellitus;
early-stage renal damage;
urine vitamin D binding protein
- MeSH:
Humans;
Diabetes Mellitus, Type 2/complications*;
Creatinine;
Vitamin D-Binding Protein/urine*;
Lipocalin-2/urine*;
Kidney/metabolism*;
Glomerular Filtration Rate;
Biomarkers
- From:
Journal of Central South University(Medical Sciences)
2023;48(1):40-48
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:The excretion of urinary vitamin D-binding protein (uVDBP) is related to the occurrence and development of early-stage renal damage in patients with Type 2 diabetes (T2DM). This study aims to explore the significance of detecting uVDBP in T2DM patients and its relationship with renal tubules, and to provide a new direction for the early diagnosis of T2DM renal damage.
METHODS:A total of 105 patients with T2DM, who met the inclusion criteria, were included as a patient group, and recruited 30 individuals as a normal control group. The general information and blood and urine biochemical indicators of all subjects were collected; the levels of uVDBP, and a marker of tubular injury [urine kidney injury molecule 1 (uKIM-1), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine retinol-binding protein (uRBP)] were detected by enzyme-linked immunosorbent assay. The results were corrected by urinary creatinine (Cr) to uVDBP/Cr, uKIM-1/Cr, uNGAL/Cr and uRBP/Cr. The Pearson's and Spearman's correlation tests were used to analyze the correlation between uVDBP/Cr and urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR) and markers of tubular injury, and multivariate linear regression and receiver operating characteristic curve were used to analyze the correlation between uVDBP/Cr and UACR or eGFR.
RESULTS:Compared with the normal control group, the uVDBP/Cr level in the patient group was increased (P<0.05), and which was positively correlated with UACR (r=0.774, P<0.01), and negatively correlated with eGFR (r=-0.397, P<0.01). There were differences in the levels of uKIM-1/Cr, uNGAL/Cr, and uRBP/Cr between the 2 groups (all P<0.01). The uVDBP/Cr was positively correlated with uKIM-1/Cr (r=0.752, P<0.01), uNGAL/Cr (r=0.644, P<0.01) and uRBP/Cr (r=0.812, P<0.01). The sensitivity was 90.0% and the specificity was 82.9% (UACR>30 mg/g) for evaluation of uVDBP/Cr on T2DM patients with early-stage renal damage, while the sensitivity was 75.0% and the specificity was 72.6% for evaluation of eGFR on T2DM patients with early-stage renal damage.
CONCLUSIONS:The uVDBP/Cr can be used as a biomarker in early-stage renal damage in T2DM patients.
