Research progress in Th17 cells and the relevant cytokines in Graves ' ophthalmopathy.
10.11817/j.issn.1672-7347.2022.220205
- Author:
Minmin JIANG
1
;
Jingxiao ZHAO
2
;
Ping WANG
2
;
Shuxun YAN
3
;
Ying WANG
4
Author Information
1. Graduate Student of 2021, Henan University of Chinese Medicine, Zhengzhou 450046. jmm137258@163.com.
2. Graduate Student of 2021, Henan University of Chinese Medicine, Zhengzhou 450046.
3. Second Ward of Endocrinology Department, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099. ysx982001@163.com.
4. Department of International Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. wangying56994@126.com.
- Publication Type:Journal Article
- Keywords:
Graves’ ophthalmopathy;
Th17 cells;
cytokines
- MeSH:
Humans;
Cytokines;
Th17 Cells;
Graves Ophthalmopathy;
Adipogenesis
- From:
Journal of Central South University(Medical Sciences)
2022;47(12):1748-1753
- CountryChina
- Language:English
-
Abstract:
Graves' ophthalmopathy is the most common clinical orbital disease, and T helper (Th) cells play an important role in the development of Graves' ophthalmopathy. Th17 cells are a major subpopulation of Th cells and abnormally highly expressed in patients with Graves' ophthalmopathy. Th17 cells and the related cytokines interleukin (IL)-17A, IL-21 and IL-23 are involved in regulating the inflammatory response, fibrosis and adipogenesis. Th17 cells are unstable and exhibit a degree of plasticity, and they can differentiate into IL-17A and interferon (IFN)-γ dual-producing Th17.1 cells, which exacerbate the pathogenicity of Th17 cells. In addition, Th17 cells and the relevant factors are strongly associated with disease activity and severity in Graves' ophthalmopathy.
