Research advances in the role of MAPK cascade in regulation of cell growth, immunity, inflammation, and cancer.
10.11817/j.issn.1672-7347.2022.220155
- Author:
Tingting GONG
1
,
2
,
3
;
Kai SI
1
,
2
,
4
;
Huiping LIU
1
,
2
,
4
;
Xiaowei ZHANG
1
,
2
,
5
Author Information
1. State Key Laboratory of Food Nutrition and Safety
2. Key Laboratory of Food Nutrition and Safety, Ministry of Education
3. College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. gong20200703@163.com.
4. College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
5. College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. zhangxw@tust.edu.cn.
- Publication Type:Journal Article
- Keywords:
cancer;
cell growth;
immunity;
inflammation;
mitogen-activated protein kinase cascade
- MeSH:
Humans;
MAP Kinase Signaling System;
Signal Transduction;
Cell Cycle;
Neoplasms;
Inflammation
- From:
Journal of Central South University(Medical Sciences)
2022;47(12):1721-1728
- CountryChina
- Language:English
-
Abstract:
Mitogen-activated protein kinase (MAPK) cascade system is one of the highly conserved signal systems in eukaryotic cells, which participates in the regulation of many biological processes. Under the stimulation of different signals (such as cytokines, neurotransmitters, and hormones), MAPK cascade activates downstream targets and controls a variety of cellular processes, including growth, immunity, inflammation, and stress response. In different cells, the effects of MAPK cascade on cells vary with the stimuli and the duration of stimulation. MAPK cascade induces Th differentiation and participates in T cell receptor signal pathway and B cell receptor signal pathway. MAPK cascades regulate various cellular activities related to the occurrence and development of cancer. A thorough and systematic understanding of the specific regulatory effects of MAPK cascade on various cellular processes will provide theoretical guidance for treating various diseases.
