Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial.
10.1007/s11655-022-3627-3
- Author:
Si-Pei LIU
1
;
Jian-Guan ZHOU
2
;
Yan JIN
3
;
Yan GUO
4
;
Shi-Wei ZHOU
2
;
Mei-Lan LIN
1
;
Jun ZHANG
2
;
Xiao-Nv WANG
2
;
Xia-Fei GUAN
2
;
Lei WANG
5
Author Information
1. Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
2. Division of Cardiovascular Rehabilitation, Ruian Hospital of Traditional Chinese Medicine, Ruian, Zhejiang Province, 325299, China.
3. Department of Rehabilitation, College of Acupuncture and Moxibustion and Massage Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
4. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
5. Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China. wanglei@njucm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Shexiang Baoxin Pill;
exercise training;
heart failure;
preserved ejection fraction
- MeSH:
Humans;
Heart Failure/therapy*;
Quality of Life;
Stroke Volume;
Exercise
- From:
Chinese journal of integrative medicine
2023;29(2):99-107
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF).
METHODS:Sixty patients with HFpEF were randomly divided into group A (n=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (n=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (n=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO2), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups.
RESULTS:After the 12-week intervention, patients in group C showed significant declines in peakVO2, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (P<0.01), while groups A and B both showed significant improvements in peakVO2, AT, 6MWT, PSQI, and SF-36 results compared with pre-treatment (P<0.01). Compared with group C, patients in groups A and B showed significant improvements in peakVO2, AT, 6MWT, PSQI, and SF-36 (P<0.01). In addition, patients in group A showed more significant improvements in physical function, role-physical, vitality, and mental health scores on the SF-36 questionnaire, and PSQI scores than those in group B (P<0.01).
CONCLUSIONS:Exercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322)).
