LOX-1 Regulation in Anti-atherosclerosis of Active Compounds of Herbal Medicine: Current Knowledge and the New Insight.
10.1007/s11655-022-3621-9
- Author:
Si-Jie YAO
1
;
Tao-Hua LAN
1
;
Xin-Yu ZHANG
1
;
Qiao-Huang ZENG
1
;
Wen-Jing XU
1
;
Xiao-Qing LI
1
;
Gui-Bao HUANG
1
;
Tong LIU
1
;
Wei-Hui LYU
1
;
Wei JIANG
2
Author Information
1. State Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510020, China.
2. State Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510020, China. jiangwei@gzucm.edu.cn.
- Publication Type:Review
- Keywords:
atherosclerosis;
herbal medicine;
lectin-like oxidized low-density lipoprotein receptor-1;
targeted therapy
- MeSH:
Humans;
Atherosclerosis;
Scavenger Receptors, Class E/physiology*;
Biomarkers;
Plant Extracts;
Lipoproteins, LDL
- From:
Chinese journal of integrative medicine
2023;29(2):179-185
- CountryChina
- Language:English
-
Abstract:
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) have recently been identified to be closely related to the occurrence and development of atherosclerosis (AS). A growing body of evidence has suggested Chinese medicine takes unique advantages in preventing and treating AS. In this review, the related research progress of AS and LOX-1 has been summarized. And the anti-AS effects of 10 active components of herbal medicine through LOX-1 regulation have been further reviewed. As a potential biomarker and target for intervention in AS, LOX-1 targeted therapy might provide a promising and novel approach to atherosclerotic prevention and treatment.
