Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis.
10.1007/s11655-022-3535-6
- Author:
Yong PENG
1
;
Xiang DENG
2
;
Shan-Shan YANG
2
;
Wei NIE
2
;
Yan-Dan TANG
2
Author Information
1. Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan Province, 412000, China. 1779342446@qq.com.
2. Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan Province, 412000, China.
- Publication Type:Review
- Keywords:
Astragalus membranaceus;
chemical components;
experimental autoimmune encephalomyelitis;
immunoregulation;
multiple sclerosis
- MeSH:
Animals;
Humans;
Astragalus propinquus/chemistry*;
Multiple Sclerosis/drug therapy*;
Encephalomyelitis, Autoimmune, Experimental/metabolism*;
Drugs, Chinese Herbal/chemistry*;
Polysaccharides
- From:
Chinese journal of integrative medicine
2023;29(1):89-95
- CountryChina
- Language:English
-
Abstract:
The primary chemical components of Astragalus membranaceus include polysaccharides, saponins, flavonoids, and amino acids. Recent studies have shown that Astragalus membranaceus has multiple functions, including improving immune function and exerting antioxidative, anti-radiation, anti-tumor, antibacterial, antiviral, and hormone-like effects. Astragalus membranaceus and its extracts are widely used in clinical practice because they have obvious therapeutic effects against various autoimmune diseases and relatively less adverse reaction. Multiple sclerosis (MS) is an autoimmune disease of central nervous system (CNS), which mainly caused by immune disorder that leads to inflammatory demyelination, inflammatory cell infiltration, and axonal degeneration in the CNS. In this review, the authors analyzed the clinical manifestations of MS and experimental autoimmune encephalomyelitis (EAE) and focused on the efficacy of Astragalus membranaceus and its chemical components in the treatment of MS/EAE.
