Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment.
10.1007/s11655-021-3301-1
- Author:
Jun-Yan XIA
1
;
Cong CHEN
2
;
Qian LIN
2
;
Jie CUI
1
;
Jie WAN
1
;
Yan LI
1
;
Dong LI
3
Author Information
1. Department of Cardiology, Dongfang Hospital, the Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100078, China.
2. Department of Cardiology, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100007, China.
3. Department of Cardiology, Dongfang Hospital, the Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100078, China. dongdong871103@163.com.
- Publication Type:Review
- Keywords:
Chinese medicine;
FUN-14 domain containing protein 1;
PTEN-induced kinase 1/Parkin;
hypoxia-inducible factor-1 α/Bcl-2 and adenovirus e1b19k Da interacting protein 3;
mitophagy;
myocardial ischemia/reperfusion injury
- MeSH:
Humans;
Mitochondria/metabolism*;
Mitophagy/genetics*;
Myocardial Reperfusion Injury;
Protein Kinases/metabolism*
- From:
Chinese journal of integrative medicine
2023;29(1):81-88
- CountryChina
- Language:English
-
Abstract:
Mitophagy is one of the important targets for the prevention and treatment of myocardial ischemia/reperfusion injury (MIRI). Moderate mitophagy can remove damaged mitochondria, inhibit excessive reactive oxygen species accumulation, and protect mitochondria from damage. However, excessive enhancement of mitophagy greatly reduces adenosine triphosphate production and energy supply for cell survival, and aggravates cell death. How dysfunctional mitochondria are selectively recognized and engulfed is related to the interaction of adaptors on the mitochondrial membrane, which mainly include phosphatase and tensin homolog deleted on chromosome ten (PTEN)-induced kinase 1/Parkin, hypoxia-inducible factor-1 α/Bcl-2 and adenovirus e1b19k Da interacting protein 3, FUN-14 domain containing protein 1 receptor-mediated mitophagy pathway and so on. In this review, the authors briefly summarize the main pathways currently studied on mitophagy and the relationship between mitophagy and MIRI, and incorporate and analyze research data on prevention and treatment of MIRI with Chinese medicine, thereby provide relevant theoretical basis and treatment ideas for clinical prevention of MIRI.
