Correlation analysis of vitamin D level and anti-Müllerian hormone in infertile female and the role in predicting pregnancy outcome.
- Author:
Xi Ya SUN
1
,
2
,
3
,
4
;
Yi Lu CHEN
1
,
2
,
3
,
4
;
Lin ZENG
5
;
Li Ying YAN
1
,
2
,
3
,
4
;
Jie QIAO
1
,
2
,
3
,
4
;
Rong LI
1
,
2
,
3
,
4
;
Xu ZHI
1
,
2
,
3
,
4
Author Information
1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital
2. National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)
3. Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education
4. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.
5. Clinical Epidemiology Research Center, Peking University Third Hospital, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Infertile female;
Pregnancy outcome;
Vitamin D;
anti-Müllerian hormone (AMH)
- MeSH:
Female;
Humans;
Pregnancy;
Anti-Mullerian Hormone;
Infertility, Female/etiology*;
Polycystic Ovary Syndrome;
Pregnancy Outcome;
Vitamin D;
Vitamins
- From:
Journal of Peking University(Health Sciences)
2023;55(1):167-173
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between serum 25(OH)D and anti-Müllerian hormone (AMH) among infertile females and their predictive impacts on in vitro fertilization and embryo transfer pregnancy outcome.
METHODS:Totally 756 infertile females treated with assisted reproductive technology were enrolled and divided into three groups according to their vitamin D levels (group A with serum 25(OH)D≤10 μg/L, group B with serum (10-20) μg/L, and group C with serum ≥20 μg/L). The serum AMH levels were detected. The differences among the groups were analyzed, as well as the correlation between vitamin D levels and serum AMH levels in various infertility types (fallopian tube/male factor, polycystic ovary syndrome (PCOS), ovulation disorders excluded PCOS, endometriosis, unexplained infertility, and others). Also, the predictive roles of vitamin D and AMH in pregnancy outcome in all the infertile females were discussed.
RESULTS:(1) 87.7% of the enrolled females were insufficient or deficient in vitamin D. (2) The serum AMH levels in the three groups with different vitamin D levels were 1.960 (1.155, 3.655) μg/L, 2.455 (1.370, 4.403) μg/L, 2.360 (1.430, 4.780) μg/L and there was no significant difference in serum AMH levels among the three groups (P>0.05). (3) Serum 25(OH)D and AMH levels presented seasonal variations (P < 0.05). (4) There was no prominent correlation between the serum AMH level and serum 25(OH)D level in females of various infertility types after adjusting potential confounding factors [age, body mass index (BMI), antral follicle count (AFC), vitamin D blood collection season, etc.] by multiple linear regression analysis (P>0.05). (5) After adjusting for confounding factors, such as age, BMI, number of transplanted embryos and AFC, the results of binary Logistics regression model showed that in all the infertile females, the serum AMH level was an independent predictor of biochemical pregnancy outcome (P < 0.05) while the serum 25(OH)D level might not act as a prediction factor alone (P>0.05). In the meanwhile, the serum 25(OH)D level and serum AMH level were synergistic predictors of biochemical or clinical pregnancy outcome (P < 0.05).
CONCLUSION:Based on the current diagnostic criteria, most infertile females had vitamin D insufficiency or deficiency, but there was not significant correlation between serum 25(OH)D and ovarian reserve. While vitamin D could not be used as an independent predictor of pregnancy outcome in infertile females, the serum AMH level could predict biochemical pregnancy outcome independently or jointly with vitamin D.
