Relationships of habitual daily alcohol consumption with all-day and time-specific average glucose levels among non-diabetic population samples.

Maho Ishihara; Hironori Imano; Isao Muraki; Kazumasa Yamagishi; Koutatsu Maruyama; Mina Hayama-terada; Mari Tanaka; Mikako Yasuoka; Tomomi Kihara; Masahiko Kiyama; Takeo Okada; Midori Takada; Yuji Shimizu; Tomotaka Sobue; Hiroyasu Iso

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Relationships of habitual daily alcohol consumption with all-day and time-specific average glucose levels among non-diabetic population samples.

Author: Maho ISHIHARA ¹ ; Hironori IMANO ¹ ; Isao MURAKI ¹ ; Kazumasa YAMAGISHI ² ; Koutatsu MARUYAMA ³ ; Mina HAYAMA-TERADA ² ; Mari TANAKA ¹ ; Mikako YASUOKA ⁴ ; Tomomi KIHARA ⁴ ; Masahiko KIYAMA ² ; Takeo OKADA ² ; Midori TAKADA ² ; Yuji SHIMIZU ² ; Tomotaka SOBUE ¹ ; Hiroyasu ISO ¹
Author Information

1. Department of Social Medicine, Osaka University Graduate School of Medicine.
2. Osaka Center for Cancer and Cardiovascular Disease Prevention.
3. Department of Bioscience, Graduate School of Agriculture, Ehime University.
4. Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba.
Publication Type:Journal Article
Keywords: Alcohol consumption; Community-based samples; Flash glucose monitoring system; Glucose levels; Non-diabetic; Time-specific
MeSH: Humans; Male; Female; Diabetes Mellitus, Type 2; Blood Glucose Self-Monitoring; Blood Glucose; Alcohol Drinking/epidemiology*; Risk Factors; Alcoholic Intoxication
From:Environmental Health and Preventive Medicine 2023;28():20-20
CountryJapan
Language:English
Abstract: BACKGROUND:Alcohol consumption is a prevalent behavior that is bi-directionally related to the risk of type 2 diabetes. However, the effect of daily alcohol consumption on glucose levels in real-world situations in the general population has not been well elucidated. This study aimed to clarify the relationship between alcohol consumption and all-day and time-specific glucose levels among non-diabetic individuals.
METHODS:We investigated 913 non-diabetic males and females, aged 40-69 years, during 2018-2020 from four communities across Japan. The daily alcohol consumption was assessed using a self-report questionnaire. All-day and time-specific average glucose levels were estimated from the interstitial glucose concentrations measured using the Flash glucose monitoring system for a median duration of 13 days. Furthermore, we investigated the association between all-day and time-specific average glucose levels and habitual daily alcohol consumption levels, using never drinkers as the reference, and performed multiple linear regression analyses after adjusting for age, community, and other diabetes risk factors for males and females separately.
RESULTS:All-day average glucose levels did not vary according to alcohol consumption categories in both males and females. However, for males, the average glucose levels between 5:00 and 11:00 h and between 11:00 and 17:00 h were higher in moderate and heavy drinkers than in never drinkers, with the difference values of 4.6 and 4.7 mg/dL for moderate drinkers, and 5.7 and 6.8 mg/dL for heavy drinkers. Conversely, the average glucose levels between 17:00 and 24:00 h were lower in male moderate and heavy drinkers and female current drinkers than in never drinkers; the difference values of mean glucose levels were -5.8 for moderate drinkers, and -6.1 mg/dL for heavy drinkers in males and -2.7 mg/dL for female current drinkers.
CONCLUSIONS:Alcohol consumption was associated with glucose levels in a time-dependent biphasic pattern.