Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2023.102.03
- Author:
Yawan JING
1
;
Hao ZENG
1
;
Ruixin CHENG
1
;
Panwen TIAN
1
;
Yalun LI
1
Author Information
1. Department of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Coping strategies;
Immunoresistance;
Immunotherapy;
Lung neoplasms
- MeSH:
Humans;
Carcinoma, Non-Small-Cell Lung/drug therapy*;
Lung Neoplasms/drug therapy*;
Prognosis;
Immunotherapy;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2023;26(1):66-77
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistance mechanisms are urgently needed. In this review, we intend to summarize the known mechanisms of immune resistance and feasible strategies, so as to provide a foundation for clinicians to develop more individualized and precise regimens and finally improve patients' prognosis.
.
