Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence
and Progression.
10.3779/j.issn.1009-3419.2023.106.02
- Author:
Limin CAO
1
;
Min WANG
1
;
Ke XU
1
Author Information
1. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
Histone and non-histone protein;
Methylation;
SETD7;
Tumor progression
- MeSH:
Humans;
Epigenesis, Genetic;
Histone-Lysine N-Methyltransferase/metabolism*;
Lysine/metabolism*;
Lung Neoplasms/genetics*;
Histones/metabolism*
- From:
Chinese Journal of Lung Cancer
2023;26(1):38-45
- CountryChina
- Language:Chinese
-
Abstract:
The occurence and development of tumors is a complicated process, which not only depends on the mutation or deletion of genes, but also is affected by epigenetic regulation. Accumulating evidences have shown that epigenetic modifications play fundamental roles in transcriptional regulation, heterochromatin formation, X chromosome inactivation, DNA damage response and tumor development. SET domain containing lysine methyltransferase 7 (SETD7) was initially identified as an important lysine methyltransferase, which methylated histone and non-histone proteins. These modifications play fundamental roles. Once this modification disorders, it can directly lead to cell abnormalities and cause many diseases. Studies have shown that SETD7 is related to the occurence and development of various tumors, but the methylation sites of SETD7 and its regulatory mechanism have not been fully elucidated. This article summarizes the research progress of the role of SETD7 on histone and non-histone methylation modification in tumors and the molecular mechanism, in order to provide new therapeutic targets for tumor pathogenesis and diagnosis.
.
