Research advances of adipose stem cell matrix gel in promoting wound healing.
10.3760/cma.j.cn501120-20211204-00404
- Author:
Nan XING
1
;
Ran HUO
2
;
Hai Tao WANG
1
;
Jin Cun YANG
1
;
Jiong CHEN
3
;
Lei PENG
1
;
Xiao Wen LIU
1
Author Information
1. Department of Burn and Plastic Surgery, Weihai Municipal Hospital, Shandong University, Weihai 264200, China.
2. Department of Plastic and Cosmetic Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
3. Department of Burn and Skin Repair Surgery, the Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Aged;
Wound Healing/physiology*;
Adipocytes;
Adipose Tissue;
Extracellular Matrix;
Stem Cells
- From:
Chinese Journal of Burns
2023;39(1):81-84
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the problem of aging population in China being prominant, the number of patients with chronic wounds such as diabetic foot, pressure ulcer, and vascular ulcer is increasing. Those diseases seriously affect the life quality of patients and increase the economy and care burden of the patients' family, which have been one of the most urgent clinical problems. Many researches have confirmed that adipose stem cells can effectively promote wound healing, while exogenous protease is needed, and there are ethical and many other problems, which limit the clinical application of adipose stem cells. Adipose stem cell matrix gel is a gel-like mixture of biologically active extracellular matrix and stromal vascular fragment obtained from adipose tissue by the principle of fluid whirlpool and flocculation precipitation. It contains rich adipose stem cells, hematopoietic stem cells, endothelial progenitor cells, and macrophages, etc. The preparation method of adipose stem cell matrix gel is simple and the preparation time is short, which is convenient for clinical application. Many studies at home and abroad showed that adipose stem cell matrix gel can effectively promote wound healing by regulating inflammatory reaction, promoting microvascular reconstruction and collagen synthesis. Therefore, this paper summarized the preparation of adipose stem cell matrix gel, the mechanism and problems of the matrix gel in promoting wound repair, in order to provide new methods and ideas for the treatment of chronic refractory wounds in clinic.
