Research Progress of Regulatory T Cells in the Pathogenesis of Multiple Myeloma --Review.
10.19746/j.cnki.issn.1009-2137.2023.01.047
- Author:
Ya-Ting LIN
1
;
Xue-Zhong GU
2
;
Jun HE
1
;
Xin GUAN
3
;
Chao-Ran ZHANG
3
Author Information
1. School of Medicine， Kunming University of Science and Technology， Kunming 650500， Yunnan Province, China,Department of Hematology, Yunnan the First People's Hospital Affiliated to Kunming University of Science and Technology (Clinical Medical Center for Blood Diseases in Yunnan Province), Kunming 650032， Yunnan Province， China.
2. Department of Hematology, Yunnan the First People's Hospital Affiliated to Kunming University of Science and Technology (Clinical Medical Center for Blood Diseases in Yunnan Province), Kunming 650032， Yunnan Province， China,E-mail: gxz76@126.com.
3. Department of Hematology, Yunnan the First People's Hospital Affiliated to Kunming University of Science and Technology (Clinical Medical Center for Blood Diseases in Yunnan Province), Kunming 650032， Yunnan Province， China.
- Publication Type:Journal Article
- Keywords:
angiogenesis;
cytokines;
immunosuppression;
multiple myeloma;
regulatory T cells;
tumor microenvironment
- MeSH:
Humans;
Multiple Myeloma/pathology*;
T-Lymphocytes, Regulatory/pathology*;
Immune Tolerance;
Plasma Cells/pathology*;
Immunosuppression Therapy;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2023;31(1):297-300
- CountryChina
- Language:Chinese
-
Abstract:
The multiple myeloma (MM), the second most common hematologic malignancy, is malignant proliferative disease of plasma cells. Although the application of many targeted drugs has significantly prolonged the survival time of MM patients, it is still an incurable disease. In recent years, the immunosuppression caused by interaction between tumor microenvironment(TME) and tumor cells has attracted people's attention gradually. As a kind of immunosuppressive cells in TME, regulatory T cells (Treg) play an important role in the progress of MM. Treg is related to the proliferation and metastasis of tumors, and can lead to the progress of MM by promoting the angiogenesis and generating immunosuppressive TME. In this review, we briefly summarized the latest research progress on the impact of Treg on the pathogenesis of MM.
