Gene Polymorphisms of Patients with Lymphoma-Associated Hemophagocytic Syndrome in Longyan area, Fujian Province.
10.19746/j.cnki.issn.1009-2137.2023.01.016
- Author:
Wei-Hao WU
1
;
Cong-Jie CHEN
1
;
Lian YU
1
;
Xiao-Mei MA
1
;
Jian-Qing HUANG
1
;
Long-Tian CHEN
2
Author Information
1. Department of Hematology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan 364000, Fujian Province, China.
2. Department of Hematology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan 364000, Fujian Province, China.E-mail: ltchen@163.com.
- Publication Type:Journal Article
- Keywords:
Fujian province;
Longyan area;
gene polymorphism;
lymphoma-associated hemophagocytic syndrome
- MeSH:
Humans;
Genotype;
Interleukin-10/genetics*;
Lymphohistiocytosis, Hemophagocytic/genetics*;
Lymphoma/genetics*;
Perforin/genetics*;
Polymorphism, Genetic
- From:
Journal of Experimental Hematology
2023;31(1):104-108
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the gene polymorphisms of patients with lymphoma-associated hemophagocytic syndrome in Longyan area, Fujian province.
METHODS:A total of 125 patients with lymphoma-associated hemophagocytic syndrome in Longyan, Fujian province, admitted to Longyan First Hospital from May 2017 to November 2020 were selected. Peripheral venous blood was collected from all the patients, and the genotypes of perforin 1 (PRF1) and interleukin-10 (IL-10) gene loci were detected by PCR-fluorescence probe method, and the correlation between PRF1 and IL-10 gene polymorphisms and lymphoma-associated hemophagocytic syndrome was analyzed.
RESULTS:The mutation frequencies of PRF1 gene loci rs885821 (C>T), rs885822 (C>T), rs1889490 (G>A) in patients with lymphoma-associated hemophagocytic syndrome were 10.40%, 78.8% and 64.4%, respectively. The mutation frequencies of rs1800872 (A>C), rs1800871 (C>T) and rs1800896 (G>A) of IL-10 loci were 56.0%, 45.2% and 77.6%, respectively.
CONCLUSION:PRF1 and IL-10 gene loci were polymorphic in patients with lymphoma-associated hemophagocytic syndrome in Longyan area, Fujian province. Alleles C and G of PRF1 and IL-10 were risk factors, and alleles T and A were protective factors.
