Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxia.
10.3724/zdxbyxb-2022-0282
- Author:
Jiaqi MAO
1
;
Lan MA
2
Author Information
1. 1. Medical Institute of Qinghai University, Xining 810001, China.
2. 2. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China.
- Publication Type:Journal Article
- Keywords:
Hypoxia;
Phenotypic transformation;
Pulmonary artery smooth muscle cells;
Review
- MeSH:
Humans;
Pulmonary Artery;
Hypertension, Pulmonary;
Vascular Remodeling/genetics*;
Hypoxia/genetics*;
Myocytes, Smooth Muscle;
Cell Proliferation/physiology*;
Cells, Cultured;
Cell Hypoxia/genetics*
- From:
Journal of Zhejiang University. Medical sciences
2023;51(6):750-757
- CountryChina
- Language:English
-
Abstract:
Phenotypic transformation of pulmonary artery smooth muscle cells (PASMCs) is a key factor in pulmonary vascular remodeling. Inhibiting or reversing phenotypic transformation can inhibit pulmonary vascular remodeling and control the progression of hypoxic pulmonary hypertension. Recent studies have shown that hypoxia causes intracellular peroxide metabolism to induce oxidative stress, induces multi-pathway signal transduction, including those related to autophagy, endoplasmic reticulum stress and mitochondrial dysfunction, and also induces non-coding RNA regulation of cell marker protein expression, resulting in PASMCs phenotypic transformation. This article reviews recent research progress on mechanisms of hypoxia-induced phenotypic transformation of PASMCs, which may be helpful for finding targets to inhibit phenotypic transformation and to improve pulmonary vascular remodeling diseases such as hypoxia-induced pulmonary hypertension.
