Research progress of fibroblast growth factor in nervous system diseases.
10.3724/zdxbyxb-2022-0180
- Author:
Wenting HUANG
1
;
Wanhua QIU
2
;
Kun CHEN
2
;
Shasha YE
2
;
Dongxue WANG
2
;
Jian HU
2
;
Huiqin XU
1
;
Li LIN
2
;
Xiaokun LI
2
Author Information
1. 1. Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
2. 2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China.
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Cerebral hemorrhage;
Cerebral infarction;
Depressive disorder;
Epilepsy;
Fibroblast growth factor;
Parkinson’s disease;
Review;
Traumatic brain injury
- MeSH:
Humans;
Fibroblast Growth Factors;
Phosphatidylinositol 3-Kinases/metabolism*;
Central Nervous System/metabolism*;
Signal Transduction/physiology*;
Alzheimer Disease
- From:
Journal of Zhejiang University. Medical sciences
2023;51(6):738-749
- CountryChina
- Language:English
-
Abstract:
Fibroblast growth factors (FGF) are a group of structurally related polypeptides which constitute an elaborate signaling system with their receptors. Evidence accumulated in the years suggests that the FGF family plays a key role in the repair of central nervous system injury. The main protective mechanisms include activating the expression of PI3K-Akt, peroxisome proliferator-activated receptor (PPARγ) and other signals; inhibiting NF-κB-mediated inflammatory response, oxidative stress and apoptosis; regulating neuronal differentiation and neuronal excitability as well as participating in protection of neurovascular units and nerve function repair. This paper comprehensively summarizes the latest research progress in FGF signaling related to diseases of the central nervous system such as cerebral infarction, cerebral hemorrhage, traumatic brain injury, Alzheimer's disease, Parkinson's disease, epilepsy and depression, aiming to provide scientific basis and reference for the development of innovative FGF drugs for the prevention and treatment of neurological diseases.
