Research progress on genetic control of host susceptibility to tuberculosis.
10.3724/zdxbyxb-2022-0484
- Author:
Wenjuan HU
;
Kaijin XU
- Publication Type:Journal Article
- Keywords:
Enrichment analysis;
Host gene;
Review;
Risk prediction;
Susceptibility;
Tuberculosis
- MeSH:
Humans;
Genome-Wide Association Study;
Tuberculosis/genetics*;
Gene Expression Regulation;
Cytokines/genetics*;
Autoimmune Diseases;
Mycobacterium tuberculosis/genetics*;
Genetic Predisposition to Disease
- From:
Journal of Zhejiang University. Medical sciences
2023;51(6):679-690
- CountryChina
- Language:English
-
Abstract:
The "Lübeck disaster", twins studies, adoptees studies, and other epidemiological observational studies have shown that host genetic factors play a significant role in determining the host susceptibility to Mycobacterium tuberculosis infection and pathogenesis of tuberculosis. From linkage analyses to genome-wide association studies, it has been discovered that human leucocyte antigen (HLA) genes as well as non-HLA genes (such as SLC11A1, VDR, ASAP1 as well as genes encoding cytokines and pattern recognition receptors) are associated with tuberculosis susceptibility. To provide ideas for subsequent studies about risk prediction of MTB infection and the diagnosis and treatment of tuberculosis, we review the research progress on tuberculosis susceptibility related genes in recent years, focusing on the correlation of HLA genes and non-HLA genes with the pathogenesis of tuberculosis. We also report the results of an enrichment analysis of the genes mentioned in the article. Most of these genes appear to be involved in the regulation of immune system and inflammation， and are also closely related to autoimmune diseases.
