Recent research on the nuclear factor-kappa B signaling pathway in cardiac injury in children with Kawasaki disease.
10.7499/j.issn.1008-8830.2209008
- Author:
Wen-Juan SUN
1
;
Yong-Hong SUN
Author Information
1. Department of Pediatrics, Gansu Provincial People's Hospital, Lanzhou 730030, China.
- Publication Type:Journal Article
- Keywords:
Child;
Kawasaki disease;
Nuclear factor-κB;
Signaling pathway
- MeSH:
Humans;
Child;
NF-kappa B;
Mucocutaneous Lymph Node Syndrome/diagnosis*;
Signal Transduction;
Incidence
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(3):250-252
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is a systemic acute vasculitis belonging to autoimmune disease. Up to now, the specific pathogenesis of this disease remains unclear, and it may involve various factors such as immune response, inflammatory response, and vascular endothelial injury caused by the activation of the nuclear factor-kappa B (NF-κB) signaling pathway. In particular, children with KD and cardiac injury tend to have a poor prognosis, and researchers hope to explore the specific pathogenesis of cardiac injury in KD to provide new options for clinical diagnosis and treatment and reduce the incidence rate of this disorder. This article reviews the recent research on the role of the NF-κB signaling pathway in cardiac injury in children with KD, so as to provide a basis for future studies.
