Influence of bronchopulmonary dysplasia on cerebral blood flow in preterm infants: a prospective study based on arterial spin labeling.
10.7499/j.issn.1008-8830.2208068
- Author:
Chen ZHANG
1
;
Wen-Li LI
1
;
Lin LU
;
Chu ZHU
1
;
Fan-Yue QIN
1
;
Meng-Jie YUAN
1
;
Qian-Ru XUE
1
;
Fa-Lin XU
1
Author Information
1. Department of Neonatology, Third Affiliated Hospital of Zhengzhou University/Henan Clinical Medical Research Center for Pediatric Diseases/Advanced Medical Research Center of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Journal Article
- Keywords:
Arterial spin labeling;
Bronchopulmonary dysplasia;
Cerebral blood flow;
Preterm infant
- MeSH:
Infant;
Pregnancy;
Female;
Infant, Newborn;
Humans;
Infant, Premature;
Bronchopulmonary Dysplasia/epidemiology*;
Prospective Studies;
Gestational Age;
Cerebrovascular Circulation
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(1):31-37
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate local cerebral blood perfusion in preterm infants with bronchopulmonary dysplasia (BPD) based on cerebral blood flow (CBF) values of arterial spin labeling (ASL).
METHODS:A prospective study was conducted on 90 preterm infants with a gestational age of <32 weeks and a birth weight of <1 500 g who were born in the Department of Obstetrics and admitted to the Department of Neonatology in the Third Affiliated Hospital of Zhengzhou University from August 2021 to June 2022. All of the infants underwent cranial MRI and ASL at the corrected gestational age of 35-40 weeks. According to the presence or absence of BPD, they were divided into a BPD group with 45 infants and a non-BPD group with 45 infants. The two groups were compared in terms of the CBF values of the same regions of interest (frontal lobe, temporal lobe, parietal lobe, occipital lobe, thalamus, and basal ganglia) on ASL image.
RESULTS:Compared with the non-BPD group, the BPD group had a significantly lower 1-minute Apgar score, a significantly longer duration of assisted ventilation, and a significantly higher incidence rate of fetal distress (P<0.05). After control for the confounding factors such as corrected age and age at the time of cranial MRI by multiple linear regression analysis, compared with the non-BPD group, the BPD group still had higher CBF values of the frontal lobe, temporal lobe, parietal lobe, occipital lobe, basal ganglia, and thalamus at both sides (P<0.05).
CONCLUSIONS:BPD can increase cerebral blood perfusion in preterm infants, which might be associated with hypoxia and a long duration of assisted ventilation in the early stage.
