Perinatal risk factors for the occurrence of singleton apparently stillborn infants.
10.7499/j.issn.1008-8830.2207108
- Author:
Min YANG
1
;
Ji-Mei WANG
1
Author Information
1. Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
- Publication Type:Randomized Controlled Trial
- Keywords:
Apparently stillborn infant;
Neonate;
Risk factor
- MeSH:
Female;
Humans;
Infant;
Infant, Newborn;
Pregnancy;
Abruptio Placentae/epidemiology*;
Apgar Score;
Breech Presentation;
Case-Control Studies;
Placenta;
Pregnancy Complications/epidemiology*;
Risk Factors;
Stillbirth
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(1):18-24
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To identify the perinatal risk factors for the occurrence of singleton apparently stillborn infants.
METHODS:This was a case-control study. A total of 154 singleton neonates with gestational age ≥28 weeks and Apgar score of 0-1 who were subsequently successfully resuscitated in the Obstetrics and Gynecology Hospital of Fudan University from January 2006 to December 2015 were enrolled as the case group (apparently stillborn group). A total of 616 singleton infants born from January 2006 to December 2015 (1-minute Apgar score >1) were randomly selected in a 1:4 ratio as the control group. Univariate analysis and multivariate logistic regression were used to analyze the perinatal risk factors for the occurrence of apparently stillborn infants.
RESULTS:The gestational age and birth weight in the apparently stillborn group were significantly lower than those in the control group (P<0.05). The incidences of fetal hydrops, cord prolapse, grade III meconium-stained amniotic fluid, placental abruption, breech presentation, severe pre-eclampsia, maternal general anesthesia at delivery, abnormal antenatal fetal heart monitoring and decreased fetal movement were significantly higher in the apparently stillborn group than those in the control group (P<0.05). The multivariate logistic analysis showed that the mother had general anesthesia at delivery (OR=34.520), decreased antenatal fetal movement (OR=28.168),placental abruption (OR=15.641), grade III meconium-stained amniotic fluid (OR=6.365), abnormal antenatal fetal heart monitoring (OR=5.739), and breech presentation (OR=2.614) were risk factors for the occurrence of apparently stillborn infants (P<0.05), while higher gestational age was a protective factor (OR=0.686, P<0.05).
CONCLUSIONS:Attention needs to be paid to mothers with abnormal prenatal fetal heart monitoring, decreased fetal movement, preterm labor, placental abruption, breech presentation, grade III meconium-stained amniotic fluid, and general anesthesia. Preparations for resuscitation should be done to rescue apparently stillborn infants.
