Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators.
- Author:
Sayuri TAKAHASHI
1
;
Ichiro TAKADA
1
Author Information
- Publication Type:Review
- Keywords: WNT5A; chromatin remodeling; histone-modifying enzymes; prostate cancer
- MeSH: Male; Humans; Wnt Signaling Pathway; Chromatin; Prostatic Neoplasms, Castration-Resistant; Chromatin Assembly and Disassembly
- From: Asian Journal of Andrology 2023;25(2):158-165
- CountryChina
- Language:English
- Abstract: Prostate cancer is one of the most common diseases in men worldwide. Surgery, radiation therapy, and hormonal therapy are effective treatments for early-stage prostate cancer. However, the development of castration-resistant prostate cancer has increased the mortality rate of prostate cancer. To develop novel drugs for castration-resistant prostate cancer, the molecular mechanisms of prostate cancer progression must be elucidated. Among the signaling pathways regulating prostate cancer development, recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, mainly that involving WNT5A, in prostate cancer progression and metastasis; however, its role remains controversial. Moreover, chromatin remodelers such as the switch/sucrose nonfermentable (SWI/SNF) complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression changes. Here, we review the roles of noncanonical WNT signaling pathways, chromatin remodelers, and epigenetic enzymes in the development and progression of prostate cancer.
