Circadian rhythm in prostate cancer: time to take notice of the clock.

Author: Wei-Zhen ZHU ¹ ; Qi-Ying HE ¹ ; De-Chao FENG ¹ ; Qiang WEI ¹ ; Lu YANG ¹
Author Information

1. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Publication Type:Review
Keywords: chronotherapy; circadian clock; circadian rhythm; prostate cancer
MeSH: Humans; Male; Carcinogenesis; Circadian Clocks/physiology*; Circadian Rhythm/physiology*; Prostatic Neoplasms/physiopathology*
From: Asian Journal of Andrology 2023;25(2):184-191
CountryChina
Language:English
Abstract: The circadian clock is an evolutionary molecular product that is associated with better adaptation to changes in the external environment. Disruption of the circadian rhythm plays a critical role in tumorigenesis of many kinds of cancers, including prostate cancer (PCa). Integrating circadian rhythm into PCa research not only brings a closer understanding of the mechanisms of PCa but also provides new and effective options for the precise treatment of patients with PCa. This review begins with patterns of the circadian clock, highlights the role of the disruption of circadian rhythms in PCa at the epidemiological and molecular levels, and discusses possible new approaches to PCa therapy that target the circadian clock.