Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older.
- Author:
Wei-Hao SHAO
1
;
Cai-Fang ZHENG
1
;
Yong-Chao GE
2
;
Xiao-Rui CHEN
1
;
Bo-Wen ZHANG
1
;
Gai-Li WANG
1
;
Wei-Dong ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: aging; lower urinary tract symptoms; postvoid residual urine volume; prostate volume; prostate-specific antigen
- MeSH: Humans; Male; Prostatic Hyperplasia/diagnosis*; Prostate-Specific Antigen; Cross-Sectional Studies; East Asian People; Risk Factors
- From: Asian Journal of Andrology 2023;25(1):132-136
- CountryChina
- Language:English
- Abstract: A cross-sectional study was conducted to estimate the age-stratified normal levels and age-related changes in the risk predictors of benign prostatic hyperplasia (BPH) progression. A total of 4706 male participants aged 40 years or older in Zhengzhou (China) were enrolled. The values of the International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA), prostate volume (PV), and postvoid residual urine volume (PVR) significantly increased with age. Nonlinear relationships between age and IPSS scores ≥8 (P for nonlinearity = 0.046), PSA level ≥1.6 ng ml-1, PV ≥31 ml, or PVR ≥39 ml (all P for nonlinearity <0.001) were observed. After the age of 61 years, the risk indicators related to BPH progression were positively correlated with age (odds ratio [OR] >1), regardless of the predictors of the IPSS score, PSA level, PV, or PVR; and the OR values increased gradually. Therefore, after the age of 61 years, the risk predictors related to BPH progression were positively correlated with age.
