Research progress of the regulatory role of autophagy in metabolic liver diseases.
10.3760/cma.j.cn501113-20201106-00601
- VernacularTitle:细胞自噬对肝脏疾病代谢的调节作用研究进展
- Author:
Yu Xian LI
1
;
Feng REN
2
;
Yu CHEN
3
Author Information
1. Beijing Institute of Technology, Beijing 100081, China.
2. Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
3. Intractable Hepatic Diseases and Artificial Liver Treatment & Training Center & Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment, Beijing 100069, China.
- Publication Type:Journal Article
- Keywords:
Cell autophagy;
Liver disease;
Metabolic regulation
- MeSH:
Humans;
Liver/metabolism*;
Liver Diseases;
Autophagy;
Metabolic Diseases;
Mitochondria
- From:
Chinese Journal of Hepatology
2023;31(1):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is one of several hepatic metabolic processes in which starved cells are supplied with glucose, free fatty acids, and amino acids to produce energy and synthesize new macromolecules. Moreover, it regulates the quantity and quality of mitochondria and other organelles. As the liver is a vital metabolic organ, specific forms of autophagy are necessary for maintaining liver homeostasis. Protein, fat, and sugar are the three primary nutrients that can be altered by different metabolic liver diseases. Drugs that have an effect on autophagy can either promote or inhibit autophagy, and as a result, it can either increase or inhibit the three major nutritional metabolisms that are affected by liver disease. Thus, this opens up a novel therapeutic option for liver disease.
