Excerpt from the 2022 American Association for the Study of Liver Diseases clinical practice guideline: management of primary sclerosing cholangitis and cholangiocarcinoma.
10.3760/cma.j.cn501113-20221226-00612
- Author:
Jie YUAN
1
;
Guo Hong HAN
1
Author Information
1. Department of Digestive and Interventional Vascular Surgery, Xi'an International Medical Center Hospital, Xi'an 710100, China.
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Diagnosis;
Follow-up;
Inflammatory bowel disease;
Primary sclerosing cholangitis;
Therapy
- MeSH:
Child;
Humans;
Cholangitis, Sclerosing/diagnosis*;
Constriction, Pathologic/complications*;
In Situ Hybridization, Fluorescence;
Cholangiocarcinoma/therapy*;
Liver Diseases/complications*;
Cholestasis;
Inflammatory Bowel Diseases/therapy*;
Bile Ducts, Intrahepatic/pathology*;
Bile Duct Neoplasms/therapy*
- From:
Chinese Journal of Hepatology
2023;31(1):35-41
- CountryChina
- Language:Chinese
-
Abstract:
What are the new contents of the guideline since 2010?A.Patients with primary and non-primary sclerosing cholangitis (PSC) are included in these guidelines for the diagnosis and management of cholangiocarcinoma.B.Define "related stricture" as any biliary or hepatic duct stricture accompanied by the signs or symptoms of obstructive cholestasis and/or bacterial cholangitis.C.Patients who have had an inconclusive report from MRI and cholangiopancreatography should be reexamined by high-quality MRI/cholangiopancreatography for diagnostic purposes. Endoscopic retrograde cholangiopancreatography should be avoided for the diagnosis of PSC.D. Patients with PSC and unknown inflammatory bowel disease (IBD) should undergo diagnostic colonoscopic histological sampling, with follow-up examination every five years until IBD is detected.E. PSC patients with IBD should begin colon cancer monitoring at 15 years of age.F. Individual incidence rates should be interpreted with caution when using the new clinical risk tool for PSC for risk stratification.G. All patients with PSC should be considered for clinical trials; however, if ursodeoxycholic acid (13-23 mg/kg/day) is well tolerated and after 12 months of treatment, alkaline phosphatase (γ- Glutamyltransferase in children) and/or symptoms are significantly improved, it can be considered to continue to be used.H. Endoscopic retrograde cholangiopancreatography with cholangiocytology brushing and fluorescence in situ hybridization analysis should be performed on all patients suspected of having hilar or distal cholangiocarcinoma.I.Patients with PSC and recurrent cholangitis are now included in the new unified network organ sharing policy for the end-stage liver disease model standard.J. Liver transplantation is recommended after neoadjuvant therapy for patients with unresectable hilar cholangiocarcinoma with diameter < 3 cm or combined with PSC and no intrahepatic (extrahepatic) metastases.
