Study of the association of lncRNA-GAS5 gene polymorphisms with systemic lupus erythematosus in Guangxi population.
10.3760/cma.j.cn511374-20210129-00094
- VernacularTitle:LncRNA-GAS5基因多态性与广西人群系统性红斑狼疮的相关性研究
- Author:
Yulan LU
1
;
Yan LAN
;
Huatuo HUANG
;
Yanxin HUANG
;
Yuxia WEI
;
Chunfang WANG
;
Chunhong LIU
Author Information
1. Reproductive Medicine Center, the Affiliated Hospital of Youjiang Minzu Medical University, Baise, Guangxi 533000, China. chunhongliu1039@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Case-Control Studies;
China/epidemiology*;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Lupus Erythematosus, Systemic/genetics*;
Nephritis;
Polymorphism, Single Nucleotide;
RNA, Long Noncoding/genetics*
- From:
Chinese Journal of Medical Genetics
2023;40(1):114-120
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of rs55829688 and rs75315904 polymorphisms of the lncRNA-GAS5 gene with susceptibility to systemic lupus erythematosus (SLE) in Guangxi population.
METHODS:Peripheral venous blood samples were collected from the SLE group and control group. Following extraction of genomic DNA, SNPscan and Sanger sequencing were carried out to determine the genotypes for the rs55829688 and rs75315904 loci of the lncRNA-GAS5 gene.
RESULTS:No difference was found between the two groups with regard to the genotypic frequencies for rs55829688 and rs75315904 (P > 0.05). However, the frequencies of C allele of rs55829688 between the two groups was significantly different (P < 0.05). In the SLE group, the frequencies of C allele and CT+CC genotype for rs55829688 among SLE patients with nephritis were significantly lower than those of SLE patients without nephritis (P < 0.05). In addition, haplotype analysis showed that the frequency of rs55829688 C/rs75315904 A allele in the SLE group was lower than that of the control group (P < 0.05).
CONCLUSION:In Guangxi population, the carrier status of rs55829688 C allele of the lncRNA-GAS5 gene may reduce the risk of SLE and its complicated nephritis, and the rs55829688 C/rs75315904 A haplotype may reduce the risk for SLE.
