Analysis of genotypes and phenotypes of three children with Cornelia de Lange syndrome.
10.3760/cma.j.cn511374-20220125-00067
- Author:
Lei ZHAO
1
;
Qinghua ZHANG
;
Bingbo ZHOU
;
Chuang ZHANG
;
Lei ZHENG
;
Yupei WANG
;
Shengju HAO
;
Ling HUI
Author Information
1. School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China. zyhuil@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Cell Cycle Proteins/genetics*;
De Lange Syndrome/diagnosis*;
Genotype;
Phenotype;
Genetic Testing;
Histone Deacetylases/genetics*;
Repressor Proteins/genetics*
- From:
Chinese Journal of Medical Genetics
2023;40(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the clinical phenotype and results of genetic testing in three children with Cornelia de Lange syndrome (CdLS).
METHODS:Clinical data of the children and their parents were collected. Peripheral blood samples of the pedigrees were collected for next generation sequencing analysis.
RESULTS:The main clinical manifestations of the three children have included growth delay, mental retardation, peculiar facies and other accompanying symptoms. Based on the criteria proposed by the International Diagnostic Consensus, all three children were suspected for CdLS. As revealed by whole exome sequencing, child 1 has harbored NIPBL gene c.5567_5569delGAA insTAT missense variant, child 2 has harbored SMC1A gene c.607A>G missense variant, and child 3 has harbored HDAC8 gene c.628+1G>A splicing variant. All of the variants were de novo in origin.
CONCLUSION:All of the children were diagnosed with CdLS due to pathogenic variants of the associated genes, among which the variants of NIPBL and HDAC8 genes were unreported previously. Above finding has enriched the spectrum of pathogenic variants underlying CdLS.
