Mutation of dentin sialophosphoprotein and hereditary malformations of dentin.
10.3760/cma.j.cn112144-20221009-00521
- Author:
Qing Lin ZHU
1
;
Xiao Hong DUAN
2
;
Qing YU
1
Author Information
1. Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University & State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Xi'an 710032, China.
2. Department of Oral Biology, School of Stomatology, The Fourth Military Medical University & State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Xi'an 710032, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Dentinogenesis Imperfecta/pathology*;
Mutation;
Extracellular Matrix Proteins/genetics*;
Phosphoproteins/genetics*;
Sialoglycoproteins/genetics*;
Dentin/pathology*
- From:
Chinese Journal of Stomatology
2023;58(1):17-24
- CountryChina
- Language:Chinese
-
Abstract:
The classification as well as the clinical manifestations of hereditary malformations of dentin are of great concern and have been deeply elucidated. The understanding of its genetic basis also increases progressively. Dentin sialophosphoprotein (DSPP) is the pathogenic gene of dentinogenesis imperfecta type Ⅱ, dentinogenesis imperfecta type Ⅲ and dentin dysplasia type Ⅱ. In this article, the classification of DSPP mutations as well as the resultant dysfunction of the mutant DSPP are summarized respectively and the corresponding clinical manifestations are analyzed. This work will provide a reference for the diagnosis and treatment of hereditary malformations of dentin.
