Correlation analysis and benchmark dose study on bone metabolic biochemical index of low doses of exposed hydrogen fluoride workers.
10.3760/cma.j.cn121094-20220328-00152
- Author:
Guang ZHENG
1
;
Feng Yi LI
2
;
Xiang WANG
3
;
Dong Qing ZHU
4
;
Zhong Lin ZHAO
3
;
Ying GUO
3
Author Information
1. Occupational Health Guidance Center, Shanghai Institute of Occupational Disease for Chemical Industry, Shanghai 200041, China.
2. Business Department, Hefei Kanghong Occupational Health Medical Examination Center, Hefei 230088, China.
3. Central Laboratory, Shanghai Institute of Occupational Disease for Chemical Industry, Shanghai 200041, China.
4. Health Care Center, Shanghai Institute of Occupational Disease for Chemical Industry, Shanghai 200041, China.
- Publication Type:Journal Article
- Keywords:
Benchmark dose;
Biochemical index;
Bone metabolism;
Hydrogen fluoride;
Low doses;
Occupational exposure;
Urinary fluoride
- MeSH:
Humans;
Fluorides/adverse effects*;
Hydrofluoric Acid;
Benchmarking;
Biomarkers;
Occupational Exposure/adverse effects*
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze correlation of occupational hydrogen fluoride exposure to low doses of bone metabolism index through occupational epidemiological investigation and benchmark dose calculation. Methods: In May 2021, using cluster sampling method, 237 workers exposed to hydrogen fluoride in a company were selected as the contact group, and 83 workers not exposed to hydrogen fluoride in an electronics production company were selected as the control group. The external exposure dose and urinary fluoride concentration, blood and urine biochemical indicators of the workers was measured.The relationship between external dose and internal dose of hydrogen fluoride was analyzed. The external dose, urinary fluoride was used as exposure biomarkers, while serum osteocalcin (BGP), serum alkaline phosphatase (AKP) and urinary hydroxyproline (HYP) were used as effect biomarkers for bone metabolism of hydrogen fluoride exposure. The benchmark dose calculation software (BMDS1.3.2) was used to calculate benchmark dose (BMD) . Results: Urine fluoride concentration in the contact group was correlated with creatinine-adjusted urine fluoride concentration (r=0.69, P=0.001). There was no significant correlation between the external dose of hydrogen fluoride and urine fluoride in the contact group (r=0.03, P=0.132). The concentrations of urine fluoride in the contact group and the control group were (0.81±0.61) and (0.45±0.14) mg/L, respectively, and the difference between the two groups was statistically significant (t=5.01, P=0.025). Using BGP, AKP and HYP as effect indexes, the urinary BMDL-05 values were 1.28, 1.47 and 1.08 mg/L, respectively. Conclusion: Urinary fluoride can sensitively reflect the changes in the effect indexes of biochemical indexes of bone metabolism. BGP and HYP can be used as early sensitive effect indexes of occupational hydrogen fluoride exposure.
