Review on biological effects and mechanism of Ac-SDKP.
10.3760/cma.j.cn121094-20220506-00238
- Author:
Ai Dong LIU
1
;
Fang YANG
2
Author Information
1. Department of Pathology, Tianjin Hospital, Tianjin 300211, China.
2. School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
- Publication Type:Journal Article
- Keywords:
Ac-SDKP;
Fibrosis;
Tumor
- MeSH:
Humans;
Oligopeptides;
Cell Transformation, Neoplastic
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(2):149-155
- CountryChina
- Language:Chinese
-
Abstract:
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is an endogenous short peptide produced through the continuous hydrolysis of Thymosin β4 by meprin-α and prolyl oligopeptidase. It has the functions of immune regulation, promoting angiogenesis, tumorigenesis and anti-fibrosis in organs. In this paper, according to some our research results and related literatures in recent years, a review of Ac-SDKP research progress was written.
