Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report.

Author: He XIN ¹ ; Ning JIAN-PING ² ; Xu HUI ² ; Xiao GONG ² ; Yang HUI-XIANG ¹ ; Wang WEI-YUAN ³ ; Wu XIAO-YING ³ ; Yin HONG-LING ³ ; Li XIAO-ZHAO ²
Author Information

1. Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.
2. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
3. Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
Publication Type:Journal Article
Keywords: amyloidosis; anti-neutrophil cytoplasmic antibody-associated vasculitis
MeSH: Female; Humans; Aged; Glomerulonephritis/diagnosis*; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology*; Antibodies, Antineutrophil Cytoplasmic; Kidney/pathology*; Amyloidosis/complications*
From: Chinese Medical Sciences Journal 2022;37(4):359-362
CountryChina
Language:English
Abstract: Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.