Progress on the design and optimization of antimicrobial peptides.
10.7507/1001-5515.202206017
- Author:
Ruonan ZHANG
1
;
Di WU
2
;
Yitian GAO
1
Author Information
1. School of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325000, P. R. China.
2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P. R. China.
- Publication Type:Journal Article
- Keywords:
Antimicrobial peptide;
Derived peptide;
Design and optimization
- MeSH:
Antimicrobial Cationic Peptides/chemistry*;
Antimicrobial Peptides;
Drug Design;
Anti-Infective Agents/pharmacology*;
Anti-Bacterial Agents
- From:
Journal of Biomedical Engineering
2022;39(6):1247-1253
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial peptides (AMPs) are a class of peptides widely existing in nature with broad-spectrum antimicrobial activity. It is considered as a new alternative to traditional antibiotics because of its unique mechanism of antimicrobial activity. The development and application of natural AMPs are limited due to their drawbacks such as low antimicrobial activity and unstable metabolism. Therefore, the design and optimization of derived peptides based on natural antimicrobial peptides have become recent research hotspots. In this paper, we focus on ribosomal AMPs and summarize the design and optimization strategies of some related derived peptides, which include reasonable primary structure modification, cyclization strategy and computer-aided strategy. We expect to provide ideas for the design and optimization of antimicrobial peptides and the development of anti-infective drugs through analysis and summary in this paper.
