Two new prenylated 2-arylbenzofurans from roots of Artocarpus heterophyllus and their anti-respiratory burst activities.
10.19540/j.cnki.cjcmm.20221114.202
- Author:
Si CHEN
1
;
Qin LUO
1
;
Hai-Ping ZHAO
2
;
Yu-Ye ZHU
1
;
Wei JIANG
1
;
Wen-Yan LI
1
;
Gang REN
1
Author Information
1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Chinese Medicine Nanchang 330004,China.
2. School of Traditional Chinese Medicine,Jiangxi University of Chinese Medicine Nanchang 330004,China.
- Publication Type:Journal Article
- Keywords:
2-arylbenzofurans;
Artocarpus heterophyllus;
anti-respiratory burst;
chemical constituents;
structure elucidation
- MeSH:
Rats;
Animals;
Molecular Structure;
Artocarpus/chemistry*;
Plant Extracts/pharmacology*;
Magnetic Resonance Spectroscopy;
Plant Roots/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(6):1553-1557
- CountryChina
- Language:Chinese
-
Abstract:
Two prenylated 2-arylbenzofurans were isolated from roots of Artocarpus heterophyllus, with a combination of various chromatographic approaches, including ODS, MCI, Sephadex LH-20, and semipreparative high performance liquid chromatography(HPLC). They were identified as 5-[6-hydroxy-4-methoxy-5,7-bis(3-methylbut-2-enyl)benzofuran-2-yl]-1,3-benzenediol(1) and 5-[2H,9H-2,2,9,9-tetramethyl-furo[2,3-f]pyrano[2,3-h][1]benzopyran-6-yl]-1,3-benzenediol(2) with spectroscopic methods, such as HR-ESI-MS, IR, 1D NMR, and 2D NMR, and named artoheterins B(1) and C(2), respectively. The anti-respiratory burst activities of the two compounds were evaluated with rat polymorphonuclear neutrophils(PMNs) stimulated by phorbol 12-myristate 13-acetate(PMA). The results showed that 1 and 2 exhibited significant inhibitory effect on respiratory burst of PMNs with IC_(50) values of 0.27 and 1.53 μmol·L~(-1), respectively.
