Alkaloids from fruit of Lycium chinense var. potaninii.
10.19540/j.cnki.cjcmm.20221114.201
- Author:
Meng-Ya HU
1
;
Wen-Jing ZHANG
1
;
Yun LIU
1
;
Yan-Jun SUN
2
;
Wei-Sheng FENG
2
;
Hui CHEN
2
Author Information
1. School of Pharmacy,Henan University of Chinese Medicine Zhengzhou 450046,China.
2. School of Pharmacy,Henan University of Chinese Medicine Zhengzhou 450046,China Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-construction by Henan Province &Education Ministry of China Zhengzhou 450046,China.
- Publication Type:Journal Article
- Keywords:
Lycium chinense var.potaninii;
alkaloids;
hypoglycemic activity
- MeSH:
Lycium/chemistry*;
Fruit/chemistry*;
Insulin Resistance;
Propionates;
Alkaloids/pharmacology*
- From:
China Journal of Chinese Materia Medica
2023;48(6):1546-1552
- CountryChina
- Language:Chinese
-
Abstract:
Ten alkaloids(1-10) were isolated from the ethyl acetate extract of the fruit of Lycium chinense var. potaninii by silica gel, ODS, and preparative high performance liquid chromatography(HPLC), and identified by NMR and MS as methyl(2S)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate(1), methyl(2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate(2), 3-hydroxy-4-ethyl ketone pyridine(3), indolyl-3-carbaldehyde(4),(R)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde(5),(R)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-car-baldehyde(6), methyl(2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(4-hydroxyphenyl)propanoate(7), dimethyl(2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanedioate(8), 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoate(9), 4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid(10). All the compounds were isolated from the plant for the first time. Among them, compounds 1-3 were new compounds. Compounds 1-9 were evaluated for hypoglycemic activity in vitro with the palmitic acid-induced insulin resistance in HepG2 cells. At 10 μmol·L~(-1), compounds 4, 6, 7, and 9 can promote the glucose consumption of HepG2 cells with insulin resistance.
