Contamination status and exposure risk of mycotoxins in Coicis Semen.
10.19540/j.cnki.cjcmm.20221205.101
- Author:
Hong-Xia ZHANG
1
;
Wei-Ke JIANG
1
;
Chang-Gui YANG
1
;
Qing-Song YUAN
1
;
Lan-Ping GUO
2
;
Yuan-Wen SHEN
1
;
Ni-Ting WEN
1
;
Jin-Qiang ZHANG
1
;
Tao ZHOU
1
Author Information
1. Resource Institute for Chinese & Ethnic Materia Medica,Guizhou University of Traditional Chinese Medicine Guiyang 550025,China.
2. National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Coicis Semen;
Monte Carlo simulation;
margin of exposure method;
mycotoxin;
risk assessment
- MeSH:
Humans;
Mycotoxins/analysis*;
Coix;
Aflatoxin B1/analysis*;
Chromatography, Liquid/methods*;
Food Contamination/analysis*;
Tandem Mass Spectrometry/methods*
- From:
China Journal of Chinese Materia Medica
2023;48(6):1491-1497
- CountryChina
- Language:Chinese
-
Abstract:
By investigating the contamination status and predicting the exposure risk of mycotoxin in Coicis Semen, we aim to provide guidance for the safety supervision of Chinese medicinal materials and the formulation(revision) of mycotoxin limit standards. The content of 14 mycotoxins in the 100 Coicis Semen samples collected from five major markets of Chinese medicinal materials in China was determined by UPLC-MS/MS. The probability evaluation model based on Monte Carlo simulation method was established after Chi-square test and One-way ANOVA of the sample contamination data. Health risk assessment was performed on the basis of margin of exposure(MOE) and margin of safety(MOS). The results showed that zearalenone(ZEN), aflatoxin B_1(AFB_1), deoxynivalenol(DON), sterigmatocystin(ST), and aflatoxin B_2(AFB_2) in the Coicis Semen samples had the detection rates of 84%, 75%, 36%, 19%, and 18%, and the mean contamination levels of 117.42, 4.78, 61.16, 6.61, and 2.13 μg·kg~(-1), respectively. According to the limit standards in the Chinese Pharmacopoeia(2020 edition), AFB_1, AFs and ZEN exceeded the standards to certain extents, with the over-standard rates of 12.0%, 9.0%, and 6.0%, respectively. The exposure risks of Coicis Semen to AFB_1, AFB2, ST, DON, and ZEN were low, while 86% of the samples were contaminated with two or more toxins, which needs more attention. It is suggested that the research on the combined toxicity of different mycotoxins should be strengthened to accelerate the cumulative exposure assessment of mixed contaminations and the formulation(revision) of toxin limit standards.
