Research and application of model fruit fly in prevention and treatment of neuropsychiatric disorders by traditional Chinese medicine and natural compounds: a review.
10.19540/j.cnki.cjcmm.20221130.401
- Author:
Rui-Ying WANG
1
;
Zhi-Fu AI
1
;
Hui-Zhen LI
1
;
Bing XUE
1
;
Ya-Li LIU
2
;
Ming YANG
3
;
Gen-Hua ZHU
1
;
Dan SU
1
;
Yong-Gui SONG
1
Author Information
1. Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Brain Diseases with Cognitive Impairment, Jiangxi Province, Jiangxi University of Chinese Medicine Nanchang 330004, China Key Research Room for Depression Syndrome Animal Models and Chinese Medicine Efficacy Evaluation (Prevention and Treatment of Mental Disorders Brain Disease) of Jiangxi Traditional Chinese Medicine Administration, Jiangxi University of Chinese Medicine Nanchang 330004, China.
2. Key Efficacy and Safety Evaluation Laboratory of Jiangxi Health Commission, Nanchang Medical College Nanchang 330004, China.
3. Jiangxi Guxiang Jinyun Comprehensive Health Industry Co., Ltd. Nanchang 330029, China.
- Publication Type:Journal Article
- Keywords:
fruit fly;
model organism;
natural compounds;
neuropsychiatric disorders;
traditional Chinese medicine
- MeSH:
Animals;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*;
Models, Animal;
Cerebrovascular Disorders
- From:
China Journal of Chinese Materia Medica
2023;48(6):1438-1445
- CountryChina
- Language:Chinese
-
Abstract:
As an important model animal, fruit fly is characterized by outstanding genetic characteristics, relatively perfect nervous system, rapid reproduction, and low cost. Thus, it has been applied in the research on neuropsychiatric disorders in recent years, showing great potential in life science. The incidence of neuropsychiatric disorders has been on the rise, and the disorders have high disability rate and low case fatality rate. The global drug demand for such diseases is second only to cardiovascular and cerebrovascular diseases. At the moment, the demand of the drugs for the diseases have been rising, and it is an urgent task to develop related drugs. However, the research and development of the drugs are time-intensive and have a high failure rate. A suitable animal model can help shorten the time for drug screening and development, thereby reducing the cost and failure rate. This study reviews the application of fruit flies in several common neuropsychiatric disorders, which is expected to provide new ideas for the research and application of the model animals in traditional Chinese medicine.
