Research advances in mechanism of lipid infiltration of coronary heart disease and simultaneous treatment of phlegm and blood stasis based on phlegm-blood stasis correlation theory.
10.19540/j.cnki.cjcmm.20221126.502
- Author:
Sen-Jie ZHONG
1
;
Jing LI
2
;
Ling-Jun WANG
3
;
Zi-Xin CHEN
3
;
Hui WU
4
;
Jie CHEN
4
;
Hong-Cheng FANG
5
;
Shao-Xiang XIAN
3
Author Information
1. the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China Postdoctoral Research Station of Guangzhou University of Chinese Medicine Guangzhou 510006, China.
2. Diagnosis Institute of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
3. the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China.
4. the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China.
5. Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine Shenzhen 518104, China.
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
coronary heart disease;
lipid metabolism;
phlegm-blood stasis correlation;
simultaneous treatment of phlegm and blood stasis
- MeSH:
Humans;
Medicine, Chinese Traditional;
Coronary Disease;
Mucus;
Atherosclerosis;
Lipids
- From:
China Journal of Chinese Materia Medica
2023;48(6):1431-1437
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(AS) is the key pathological basis of coronary heart disease(CHD), and lipid infiltration is a classical theory to explain the pathological mechanism of AS. The theory highlights that the occurrence and development of AS are closely related to abnormal lipid metabolism, with the essence of the pathological reaction caused by the invasion of lipids into arterial intima from plasma. Phlegm and blood stasis are physiologically homologous and subject to pathological co-existence. Phlegm-blood stasis correlation is the basic theory to explain the pathogenesis characteristics of CHD and has important guiding significance for revealing the mecha-nism of lipid infiltration of CHD. Phlegm is the pathological product of abnormal metabolism of Qi, blood, and body fluid, and a gene-ral summary of a series of abnormally expressed lipid substances. Among them, turbid phlegm invades the heart vessels, gradually accumulates, and condenses to achieve the qualitative change from "invisible pathogen" to "tangible pathogen", which corresponds to the mechanism of lipid migration and deposition in the intima of blood vessels, and is the starting factor of the disease. Blood stasis is the continuous development of phlegm, and it is a result of pathological states such as decreased blood fluidity, increased blood coagulation, and abnormal rheology. The fact that blood stasis caused by phlegm accords with the pathological process of "lipid abnormality-circulatory disturbance" and is the central link of the disease. Phlegm and blood stasis aggravate each other and lead to indissoluble cementation. The phlegm-blood stasis combination serves as common pathogen to trigger the disease, which is the inevitable outcome of the disease. Based on the phlegm-blood stasis correlation theory, the simultaneous treatment of phlegm and blood stasis is established. It is found that this therapy can simultaneously regulate blood lipid, reduce blood viscosity, and improve blood circulation, which can fundamentally cut off the biological material basis of the reciprocal transformation between phlegm and blood stasis, thus exerting a significant curative effect.
