Chemical reaction mechanism of decoction of traditional Chinese medicines: a review.
10.19540/j.cnki.cjcmm.20221020.601
- Author:
Chang-Jiang-Sheng LAI
1
;
Ze-Yan CHEN
1
;
Zi-Dong QIU
1
;
You-Run CHEN
1
;
Chong-Yang WANG
1
;
Nan-Ju MEI
1
;
Jin-Rui LIU
1
Author Information
1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
aconitine;
chemical reaction mechanism;
decoction of traditional Chinese medicines;
electrospray ionization mass spectrometry;
ginseng;
self-assembling
- MeSH:
Medicine;
Medicine, Chinese Traditional;
Research Design
- From:
China Journal of Chinese Materia Medica
2023;48(4):890-899
- CountryChina
- Language:Chinese
-
Abstract:
Complicated chemical reactions occur in the decoction of traditional Chinese medicines(TCMs) which features complex components, influencing the safety, efficacy, and quality controllability of TCMs. Therefore, it is particularly important to clarify the chemical reaction mechanism of TCMs in the decoction. This study summarized eight typical chemical reactions in the decoction of TCMs, such as substitution reaction, redox reaction, isomerization/stereoselective reaction, complexation, and supramolecular reaction. With the "toxicity attenuation and efficiency enhancement" of aconitines and other examples, this study reviewed the reactions in decoction of TCMs, which was expected to clarify the variation mechanisms of key chemical components in this process and to help guide medicine preparation and safe and rational use of medicine in clinical settings. The current main research methods for chemical reaction mechanisms of decoction of TCMs were also summed up and compared. The novel real-time analysis device of decoction system for TCMs was found to be efficient and simple without the pre-treatment of samples. This device provides a promising solution, which has great potential in quantity evaluation and control of TCMs. Moreover, it is expected to become a foundational and exemplary research tool, which can advance the research in this field.
