Review of traditional Chinese medicines in ameliorating neuropsychiatric diseases by improving the levels of monoamine neurotransmitters via gut microbiota regulation.
10.19540/j.cnki.cjcmm.20221103.601
- Author:
Xiao-Lu HU
1
;
Xia WU
1
Author Information
1. Key Laboratory of Collateral Disease Theory Research, School of Traditional Chinese Medicine,Capital Medical University Beijing 100069, China.
- Publication Type:Review
- Keywords:
bacteria-gut-brain axis;
gut microbiota;
monoamine neurotransmitters;
neuropsychiatric diseases;
traditional Chinese medicines
- MeSH:
Humans;
Administration, Oral;
Alzheimer Disease;
Brain-Gut Axis;
Gastrointestinal Microbiome;
Neurotransmitter Agents
- From:
China Journal of Chinese Materia Medica
2023;48(4):853-860
- CountryChina
- Language:Chinese
-
Abstract:
The degeneration of monoaminergic system and the reduction of monoamine neurotransmitters(MNTs) are associated with the occurrence of a variety of neuropsychiatric diseases, becoming the key indicators for clinical diagnosis and treatment. Recent studies suggested gut microbiota could influence the occurrence, development, and treatment of neuropsychiatric diseases by directly or indirectly regulating the synthesis and metabolism of MNTs. Rich clinical experience has been accumulated in the amelioration and treatment of neuropsychiatric diseases by traditional Chinese medicines. The traditional oral administration method demonstrates obvious advantages in regulating gut microbiota. It provides a new idea for explaining the pharmacodynamic material basis and mechanism of traditional Chinese medicines in ameliorating neuropsychiatric disease by improving the levels of MNTs via gut microbiota regulation. Focusing on three common neuropsychiatric diseases including Alzheimer's disease, Parkinson's disease, and major depression, we summarized the pathways of gut microbiota in regulating the levels of MNTs and the paradigms of traditional Chinese medicines in ameliorating neuropsychiatric diseases via the "bacteria-gut-brain axis", aiming to provide ideas for the development of drugs and treatment schemes.
