Cembranoids and their bioactivities in soft coral Sarcophyton glaucum.
10.19540/j.cnki.cjcmm.20220905.201
- Author:
Min WU
1
;
Kai-Bing ZHOU
2
;
Hao-Fu DAI
3
;
Yan-Bo ZENG
4
Author Information
1. School of Horticulture, Hainan University Haikou 570228, China Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
2. School of Horticulture, Hainan University Haikou 570228, China.
3. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
4. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China Zhanjiang Experiment Station, Chinese Academy of Tropical Agricultural Sciences Zhanjiang 524013, China.
- Publication Type:Journal Article
- Keywords:
Sarcophyton glaucum;
cembranoids;
chemical constituents;
cytotoxic activity;
soft coral
- MeSH:
Animals;
Anthozoa;
Acetylcholinesterase;
Cell Line, Tumor
- From:
China Journal of Chinese Materia Medica
2023;48(3):707-714
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents in soft coral Sarcophyton glaucum were separated and purified by various chromatographic methods. Based on the spectral data, physicochemical properties, and comparison with the data reported in the literature, nine cembranoids, including a new cembranoid named sefsarcophinolide(1) together with eight known cembranoids, namely(+)-isosarcophine(2), sarcomilitatin D(3), sarcophytonolide J(4),(1S,3E,7E,13S)-11,12-epoxycembra-3,7,15-triene-13-ol(5), sarcophytonin B(6),(-)-eunicenone(7), lobophytin B(8), and arbolide C(9), were identified. As revealed by biological activity experiment results, compounds 2-6 had weak acetylcholinesterase inhibitory activity, and compound 5 displayed weak cytotoxicity against K562 tumor cell line.
