Eleven new sesquiterpenoids from peeled stems of Syringa pinnatifolia.
10.19540/j.cnki.cjcmm.20220712.201
- Author:
Hong-Ying CHEN
1
;
Shun-Gang JIAO
1
;
An-Ni LI
1
;
Chang-Xin LIU
1
;
Pan-Long CHEN
1
;
Su-Yi-le CHEN
2
;
Juan LIU
3
;
Peng-Fei TU
1
;
Xing-Yun CHAI
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine,Beijing Academy of Traditional Chinese Medicine,Beijing University of Chinese Medicine Beijing 100029,China.
2. Alashan League Mongolian Medicine Hospital Alxa Left,Banner 750300,China.
3. National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Mongolian folk medicine;
alashanoids;
peeled stems of Syringa pinnatifolia;
pinnatanoids;
sesquiterpenoids
- MeSH:
Syringa;
Sesquiterpenes;
Terpenes;
Asthma;
Chromatography, Liquid
- From:
China Journal of Chinese Materia Medica
2023;48(3):689-699
- CountryChina
- Language:Chinese
-
Abstract:
The peeled stems of Syringa pinnatifolia(SP) is a representative Mongolian folk medicine with the effects of anti-depression, heat clearance, pain relief, and respiration improvement. It has been clinically used for the treatment of coronary heart disease, insomnia, asthma, and other cardiopulmonary diseases. As part of the systematic study on pharmacological substances of SP, 11 new sesquiterpenoids were isolated from the terpene-containing fractions of the ethanol extract of SP by liquid chromatography-mass spectrometry(LC-MS) and proton nuclear magnetic resonance(~1H-NMR) guided isolation methods. The planar structures of the sesquiterpenoids were identified by MS, 1D NMR, and 2D NMR data analysis, and were named pinnatanoids C and D(1 and 2), and alashanoids T-ZI(3-11), respectively. The structure types of the sesquiterpenoids included pinnatane, humulane, seco-humulane, guaiane, carryophyllane, seco-erimolphane, isodaucane, and other types. However, limited to the low content of compounds, the existence of multiple chiral centers, the flexibility of the structure, or lack of ultraviolet absorption, the stereoscopic configuration remained unresolved. The discovery of various sesquiterpenoids enriches the understanding of the chemical composition of the genus and species and provides references for further analysis of pharmacological substances of SP.
