Three-dimensional multi-component analysis of Aurantii Fructus quality and research on influencing factors.
10.19540/j.cnki.cjcmm.20221015.101
- Author:
Zi-Xuan LIU
1
;
Xue-Sen FU
1
;
Ling WANG
1
;
Xiang-Dan LIU
1
;
Ri-Bao ZHOU
1
Author Information
1. School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Key Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province Changsha 410208, China Key Laboratory of Modern Research of Traditional Chinese Medicine, Education Department of Hunan Province Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
Aurantii Fructus;
indicator components;
quality evaluation;
three-dimensional multi-component
- MeSH:
Citrus;
Flavonoids/analysis*;
Drugs, Chinese Herbal;
Fruit/chemistry*;
Coumarins/analysis*;
Chromatography, High Pressure Liquid/methods*
- From:
China Journal of Chinese Materia Medica
2023;48(1):265-272
- CountryChina
- Language:Chinese
-
Abstract:
The present study explored the consistency of the content proportions of active components of Aurantii Fructus and analyzed the influencing factors based on three-dimensional multi-component analysis. A total of 839 Aurantii Fructus samples in 65 research articles were analyzed using the three-dimensional multi-component analysis mode. The content data of flavonoid components(naringin, hesperidin, neohesperidin, narirutin, and nobiletin), coumarin components(meranzin and gluconolactone), and alkaloid(synephrine) in 386 samples which met the criteria of 2020 edition of the Chinese Pharmacopoeia were extracted and adjusted to percentages, and the content ratios between components were calculated. The influencing factors of Aurantii Fructus quality were analyzed. The results showed content ratios of components as follows: neohesperidin∶naringin in the range of 0.4-1.2; narirutin∶naringin in the range of 0.02-0.16; hesperidin∶naringin in the range of 0.01-0.3; nobiletin∶naringin in the range of 0.000 588 3-0.069 68; synephrine∶naringin in the range of 0.02-0.042; gluconolactone∶naringin in the range of 0.001-0.01; meranzin∶naringin in the range of 0.000 4-0.035. The quality of Aurantii Fructus was closely related to the origin, variety, harvesting time, and processing method of medicinal materials. Harvesting time had a greater impact on the quality of Aurantii Fructus, and the origin and variety had a certain impact on the quality of Aurantii Fructus. The findings of this study indicated that the ratios between flavonoid components, flavonoids and coumarin components, and flavonoids and alkaloids fluctuated. The production base should optimize the varieties, harvesting period, and processing methods of Aurantii Fructus to provide a scientific basis for the production of high-quality Aurantii Fructus.
