Diterpenoid constituents in Pseudolarix amabilis and their antitumor activities in vitro.
10.19540/j.cnki.cjcmm.20220427.201
- Author:
Shang-Yi WANG
1
;
Yu-Xun ZHU
1
;
Zhao-Xin ZHANG
1
;
Cheng-Shuo YANG
1
;
Hui-Min XIA
1
;
Guo-Zhu SU
1
;
Yong LI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Pseudolarix amabilis;
antitumor activity;
diterpenoids
- MeSH:
Humans;
Molecular Structure;
Neuroblastoma;
Diterpenes/chemistry*;
Antineoplastic Agents
- From:
China Journal of Chinese Materia Medica
2023;48(1):96-104
- CountryChina
- Language:Chinese
-
Abstract:
By various chromatographic techniques and extensive spectroscopic methods, 17 abietane diterpenoids were isolated from the dichloromethane fraction of the 95% ethanol cold-soak extracts of the seeds of Pseudolarix amabilis, namely pseudoamaol A(1), 12α-hydroxyabietic acid(2), 12-methoxy-7,13-abietadien-18-oic acid(3), 13-hydroxy-8,11,13-podocarpatrien-18-oic acid(4), 15-hydroxy-7,13-abietadien-12-on-18-oic acid(5), 8(14)-podocarpen-13-on-18-oic acid(6), holophyllin K(7), metaglyptin B(8), 7α-hydroxydehydroabietinsaure-methylester(9), 7-oxodehydroabietic acid(10), 15-hydroxy-7-oxodehydroabietinsaure-methy-lester(11), 15-methoxydidehydroabietic acid(12), 7-oxo-15-hydroxy-dehydroabietic acid(13), 15-hydroxydehydroabietic acid(14), 8,11,13-abietatriene-15,18-diol(15), 8,11,13-abietatriene-15-hydroxy-18-succinic acid(16), and 7β-hydroxydehydroabie-tic acid(17). Compound 1 was a new compound. The isolated compounds were evaluated for their antitumor activities(HepG2, SH-SY5Y, K562), and compounds 8 and 17 showed potential cytotoxic activity against K562 cells, with IC_(50) values of 26.77 and 37.35 μmol·L~(-1), respectively.
