Application of microneedle-assisted percutaneous drug delivery system in treatment of rheumatoid arthritis:a review.
10.19540/j.cnki.cjcmm.20221013.601
- Author:
Xiao LIANG
1
;
Ya-Lan LI
1
;
Jun-Hao ZHANG
1
;
Hao-Tian BAI
1
;
Shu-Hui SUN
1
;
Qian-Qian ZHANG
1
;
Jing YANG
2
;
Rui WANG
1
Author Information
1. College of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150040, China.
2. Basic Medical College, Heilongjiang University of Chinese Medicine Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
microneedle;
new technology;
percutaneous;
research progress;
rheumatoid arthritis
- MeSH:
Humans;
Drug Delivery Systems;
Administration, Cutaneous;
Pharmaceutical Preparations;
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use*;
Arthritis, Rheumatoid/drug therapy*;
Needles
- From:
China Journal of Chinese Materia Medica
2023;48(1):13-21
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA) is a chronic degenerative joint disease characterized by inflammation. Due to the complex causes, no specific therapy is available. Non-steroidal anti-inflammatory agents and corticosteroids are often used(long-term, oral/injection) to interfere with related pathways for reducing inflammatory response and delaying the progression of RA, which, however, induce many side effects. Microneedle, an emerging transdermal drug delivery system, is painless and less invasive and improves drug permeability. Thus, it is widely used in the treatment of RA and is expected to be a new strategy in clinical treatment. This paper summarized the application of microneedles in the treatment of RA, providing a reference for the development of new microneedles and the expansion of its clinical application.
