Two pairs of phloroglucinol enantiomers from Hypericum wightianum and their stereochemical structures.
10.19540/j.cnki.cjcmm.20220612.202
- Author:
Rui-Fei ZHANG
1
;
Yan-Xiao FAN
1
;
Yuan-Yuan JI
1
;
Chun-Lin LONG
2
Author Information
1. Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China College of Life and Environmental Sciences, Minzu University of China Beijing 100081, China.
2. Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China College of Life and Environmental Sciences, Minzu University of China Beijing 100081, China Key Laboratory of Ethnomedicine (Minzu University of China), Ministry of Education Beijing 100081, China Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China.
- Publication Type:Journal Article
- Keywords:
Hypericum;
Hypericum wightianum;
chemical constituent;
phloroglucinol
- MeSH:
Phloroglucinol;
Hypericum/chemistry*;
Molecular Structure;
Magnetic Resonance Spectroscopy;
Drugs, Chinese Herbal/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(2):421-429
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents in the ethanol extract of Hypericum wightianum(Hypericaceae) were purified by column chromatography and identified via magnetic resonance imaging(NMR), high-resolution mass spectrum, and circular dichroism. A total of 22 compounds were identified, including eight polyprenylated phloroglucinols(1-8), three chromones(9-11), and three terpenoids(14-16) and so on. Among them, compounds 16 and 17 were first reported in the genus Hypericum, and compounds 1-11, 14, 15, and 19 were first isolated from H. wightianum. Compounds 1-4 were previously reported as two pairs of enantiomers. This study reported the chiral resolutions and absolute configurations of compounds 1-4 for the first time.
