Effect of traditional Chinese medicine in attenuating chronic kidney disease and its complications by regulating gut microbiota-derived metabolite trimethylamine N-oxide: a review.
10.19540/j.cnki.cjcmm.20220726.501
- Author:
Chen YONG
1
;
Guo-Shun HUANG
1
;
Hong-Wei GE
1
;
Qing-Min SUN
1
;
Kun GAO
1
;
En-Chao ZHOU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
complication;
traditional Chinese medicine;
treatment strategy;
trimethylamine N-oxide
- MeSH:
Humans;
Gastrointestinal Microbiome;
Medicine, Chinese Traditional;
Renal Insufficiency, Chronic/drug therapy*
- From:
China Journal of Chinese Materia Medica
2023;48(2):321-328
- CountryChina
- Language:Chinese
-
Abstract:
Trimethylamine N-oxide(TMAO), a metabolite of gut microbiota, is closely associated with chronic kidney disease(CKD). It can aggravate the kidney injury and promote the occurrence of complications of CKD mainly by inducing renal fibroblast activation, vascular endothelial inflammation, macrophage foaming, platelet hyperreactivity, and inhibition of reverse cholesterol transport. Thus it is of great significance for clinical treatment of CKD to regulate circulating TMAO and alleviate its induced body damage. Currently, therapeutic strategies for TMAO regulation include dietary structure adjustment, lifestyle intervention, intestinal microflora regulation, and inhibition of intestinal trimethylamine synthesis and liver trimethylamine oxidation. Chinese medicinal herbs have the clinical advantage of multi-component and multi-target effects, and application of traditional Chinese medicine(TCM) to synergistically regulating TMAO and improving CKD via multiple pathways has broad prospects. This study systematically reviewed the clinical relevance and mechanism of TMAO in aggravating CKD renal function deterioration and complication progression. In addition, the effect and mechanism of TCM in improving TMAO-induced kidney injury, cardiovascular disease, hyperlipidemia, thrombosis and osteoporosis were summarized. The results provided a theoretical basis for TCM in attenuating gut microbiota-derived metabolite TMAO and improving CKD, as well as a basis and direction for in-depth clinical development and mechanism research in the future.
