Oral absorption and effect of macromolecules in traditional Chinese medicine: a new perspective and research mode of phase structure.
10.19540/j.cnki.cjcmm.20220930.601
- Author:
Hang XIAO
1
;
Ju HUANG
2
;
Xiang-Rui MENG
2
;
Yi-Ning ZHANG
1
;
Jing LI
1
;
Li MA
1
Author Information
1. College of Traditional Chinese Medicine, Capital Medical University Beijing 100069, China.
2. TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610075, China.
- Publication Type:Journal Article
- Keywords:
effect form;
oral absorption;
phase structure;
polysaccharides;
protein peptides;
structural traditional Chinese medicine;
structure-activity relationship
- MeSH:
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/chemistry*;
Stomach;
Administration, Oral
- From:
China Journal of Chinese Materia Medica
2023;48(2):285-291
- CountryChina
- Language:Chinese
-
Abstract:
Protein polypeptides and polysaccharides, the indispensable macromolecular active components in traditional Chinese medicine, are widely found in Chinese medicine decoction after the decoction of traditional Chinese medicine. However, through oral administration, these macromolecules are digested by the stomach and intestine and thus fail to be absorbed in prototype. This is inconsistent with the actual clinical efficacy of Chinese medicine decoction. According to modern research, new phase structures and effects of the macromolecules emerge during the decoction of traditional Chinese medicine, but the phase change law caused by the interaction among the components of traditional Chinese medicine and the relationship between phase structure and effect are still unclear. Thus, this study reviewed the oral absorption of macromolecular components of traditional Chinese medicine, analyzed the internal relationship of the form of macromolecules in traditional Chinese medicine with the absorption and effect based on phase structure, and summarized the research mode of oral absorption and effect of macromolecules in traditional Chinese medicine with phase structures as the core, providing new ideas and methods for future research.
